Please try not to worry. The ANA needs to be interpreted in the clinical setting to be properly evaluated. The ANA test detects these autoantibodies in the blood. Antinuclear antibodies (ANA) are a group of autoantibodies produced by a person's immune system when it fails to adequately distinguish between "self" and "nonself." Can have false positive even with high titer. Patterns reported include Homogeneous, Speckled, Nucleolar, Centromere, and SSA Ro. G. greatgran Member . ESR was a 5 (negative), RF/nephelometry was a 9 (neg), CRP was a 5 (neg), ANCA was negative, CBC was within normal level, wbc auto, liver and urine all "WNL" cept, urine had a trace of proteinand RBC was 4-10. Results are measured in titers. However, when the immune system can “see” the nuclear contents for longer periods of time, it can mount a significant antibody response. Connect by text or video with a U.S. board-certified doctor now — wait time is less than 1 minute! ANA react with components of the body's own healthy cells and cause signs and symptoms such as tissue and organ inflammation, joint and muscle pain, and fatigue. 1:320), the result is less clear and should be interpreted in the clinical context, If the ANA titre is high, other tests may be ordered to determine what type of nuclear protein is being attacked. The ANA test is not specific to a single disease. An ANA of only 1:80 is borderline at most. 1 doctor agrees. The test is repeated every time it is positive by diluting the sample to 1:160, 1:320, 1:640, 1:1280, and finally 1:2560. A and B, Distribution of antinuclear antibody (ANA)–positive healthy individuals (HI) and patients with autoimmune rheumatic disease (ARD) according to titer for all patterns combined on the ANA–HEp‐2 test (A) and for the nuclear fine speckled pattern on the ANA–HEp‐2 test (B). mrs.tee. I'm going to have the test run again because these are a year old now. I also learned this can cause joint/muscle pain and a positive ANA (due to the hypothyroidism... (20 replies) As a general rule, if a person’s ANA test is negative, then they do not have lupus. Other examples of rheumatic diseases that might have a positive ANA test include: A positive ANA test does not necessarily mean a person has an autoimmune disease. Any sample identified as positive at the screening dilution is titered out either to endpoint or to a pre-defined dilution, depending on the laboratory’s preference. Every lab has different cut off values, but in general, an ANA of 1:80 is typically considered positive. In my labs it shows a positive ANA and then the lab automatically checks for antibodies...The only one was a low positive rnp..What does that mean? https://healthresearchfunding.org/ana-titer-blood-test-results-fully-explained Presence of ANA in dilutions less than 80 are not diagnostic may need Radiology and or synovial tap to establish diagnosis Send thanks to the doctor 90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. I have many rnp positive pts with no illness. A positive ANA test means that a person may have an autoimmune disease, depending on the titre. The ANA test itself is insufficient to provide all the information needed to help in the diagnosis and management of anyone with autoimmune symptoms (which you don't have). My ANA was ran twice (2 months apart) and both times were 1: 80, speckled pattern. The lowest dilution is 1:2560. The ANA test is a simple screening test to look for antibodies in the blood that are attacking proteins in the nucleus. Recently i have done several blood test and found that the Antinuclear Antibody Test(ANA) is positive with Titre 1:80 Speckled Pattern. The ANA test is like using a radar fish finder. There are several patterns of anti-nuclear antibodies. Sending an ANA test under these exploratory circumstanc… the “titre”). For the ANA test, 1 part of the serum is diluted into 40 parts of diluent (called a “1:40” titre). 0 thank. From an internet search, I found this also: "A positive ANA titer can be found in a variety of rheumatologic diseases, such as lupus or rheumatoid arthritis. Some conditions associated with a speckled ANA are SLE, Sjögren syndrome, scleroderma, polymyositis, rheumatoid arthritis and mixed connective tissue disease but before you start thinking "lupus and other related deseases", you need to know more about this test. 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